AMY-101, INHIBITOR of Complement C3 inhibitor, CAS No.rp173457, INHIBITOR of Complement C3 inhibitor

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In stock
Item Number
rp173457
Grouped product items
SKU Size Availability Price Qty
rp173457-500μg
500μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,334.90
rp173457-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,334.90

Basic Description

Product Name AMY-101, INHIBITOR of Complement C3 inhibitor, CAS No.rp173457
Synonyms Compstatin 40 | AMY-101 | 1427001-89-5 | 4Z4DFR9BX7 | CP40 | S3,S13-Cyclo(D-tyrolsyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-aspartyl-L-tryptophyl-N-methyl-L-glycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N-methyl-L-isoleucinamide) | UN
Grade Moligand™
Specifications & Purity Moligand™
Action Type INHIBITOR
Mechanism of action INHIBITOR of Complement C3 inhibitor

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CAS rp173457

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Genetic information

Alternate Names Compstatin 40|AMY-101|1427001-89-5|4Z4DFR9BX7|CP40|S3,S13-Cyclo(D-tyrolsyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-aspartyl-L-tryptophyl-N-methyl-L-glycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N-methyl-L-isoleucinamide)|UN
Reference
  • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
  • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
  • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
  • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
  • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
  • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
  • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
  • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
  • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
  • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

References

1. Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, DeAngelis RA, Resuello RR, Lupu F et al..  (2013)  New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties..  Immunobiology,  218  (4): (496-505).  [PMID:22795972] [10.1021/op500134e]
2. Maekawa T, Briones RA, Resuello RR, Tuplano JV, Hajishengallis E, Kajikawa T, Koutsogiannaki S, Garcia CA, Ricklin D, Lambris JD et al..  (2016)  Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3..  J Clin Periodontol,  43  (3): (238-49).  [PMID:26728318] [10.1021/op500134e]
3. Maekawa T, Abe T, Hajishengallis E, Hosur KB, DeAngelis RA, Ricklin D, Lambris JD, Hajishengallis G.  (2014)  Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis..  J Immunol,  192  (12): (6020-7).  [PMID:24808362] [10.1021/op500134e]
4. Chen J, Wang W, Tang Y, Huang XR, Yu X, Lan HY.  (2021)  Inflammatory stress in SARS-COV-2 associated Acute Kidney Injury..  Int J Biol Sci,  17  (6): (1497-1506).  [PMID:33907513] [10.1021/op500134e]
5. Nilsson B, Persson B, Eriksson O, Fromell K, Hultström M, Frithiof R, Lipcsey M, Huber-Lang M, Ekdahl KN.  (2022)  How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment..  Front Immunol,  13  (13): (840137).  [PMID:35350780] [10.1021/op500134e]

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