Bioactivity:Measured by its binding ability in a functional ELISA. Immobilized recombinant human ITGa4 at 2 μg/ml(100 μl/well) can bind Human VCAM-1, the ED50 for this effect is 0.261 µg/mL.
Bioactivity:Measured by its ability to cleave a colorimetric peptide substrate, 1O-hexadecyl-2-deoxy-2-thio Sacetylsnglyceryl-3-phosphoryl choline (2- Thio-PAF), in the presence of 5, 5’Dithiobis(2-nitrobenzoic acid) (DTNB). The specific activity is >5000 pmoles/min/μg.
Bioactivity:Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit sRANK Ligand induced nuclear factor kappa B(NFkappaB) in RAW 264.7 cells is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg in the presence of 15 ng/ml of recombinant sRANK Ligand.
Synonyms: CD 265 | CD265 | FEO | LOH18CR1 | Loss of heterozygosity 18 chromosomal region 1 | mRANK | ODFR | OFE | OPTB7 | Osteo...
Bioactivity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat Nb2-11 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0 × 10^6 IU/mg.
Bioactivity:Fully biologically active when compared to standard. The ED50 as determined by neutralizing the stimulation of U937 cells is less than 10 ng/ml in the presence of 10 ng/mL soluble rHuRANKL (sRANKL).
Bioactivity:1. Measured by its ability to inhibit the IL-2-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 for this effect is 0.2 ‑1.2 µg/mL in the presence of 30 ng/mL of recombinant human IL-2. 2. Immobilized Recombinant Human IL-2 Protein (rp156004) at 1 μg/mL can bind biotinylated Recombinant Human IL-2 Receptor Alpha Protein (rp147480).
Bioactivity:1. Immobilized Recombinant Human IL-6 Protein at 2 μg/mL can bind Recombinant Human IL-6R Protein (rp147628) the EC50 is 8.0 - 24.0 ng/mL. 2. Measured by its ability to enhance the IL-6 activity on M1 mouse myeloid leukemia cells. The ED50 for this effect is typically 10.0 - 60.0 ng/mL.3. Using the Octet RED System, the affinity constant (Kd) of Recombinant Human IL-6R Protein (rp147628) bound Anti-IL6R Antibody was 0.1 nM.
Bioactivity:Measured by the ability of the immobilized protein to support the adhesion of human monocyte-derived dendritic cells. When 5 x 104 cells/well are added to human CD83/Fc Chimera coated plates (5 µg/mL, 100 µL/well), approximately 50-75% will adhere after 30 minutes at 37° C.
Synonyms: B-cell activation protein | BL11 | BL11CD83 antigen | CD83 antigen (activated B lymphocytes, immunoglobulin superfami...
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