What is the difference between Mouse CD90 and CD90.1 and CD90.2?

What is the difference between Mouse CD90 and CD90.1 and CD90.2?

CD90, also known as Thy1 (thymus cell antigen 1), is a mouse immune cell surface molecule. In mice, there are two major isoforms of CD90: CD90.1 and CD90.2. The difference between these two isoforms stems from allelic differences at the locus of the gene.CD90.1 and CD90.2 are expression variants controlled by different alleles of the gene. For example, in C57BL/6 mice, CD90.1 expression is regulated by the Ly5.2 locus, whereas CD90.2 is controlled by the Ly5.1 locus. Due to the differences in the CD90.1 and CD90.2 motifs, these isoforms can be utilized for labeling in experiments to distinguish between cells of different origins. By introducing genetic isoforms of CD90.1 or CD90.2, cells can be genetically labeled to identify, track, and quantitatively analyze cells of specific origin.

CD90 can be expressed on hematopoietic stem cells, neurons, all thymocytes, and peripheral T cells. Mouse strains expressing CD90.1 include AKR, BDP, MA/MyJ, etc., and more mouse strains expressing CD90.2 include Balb/c, CBA/J, C3H/He, C57BL/-, DBA, NZB/-, etc.

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