Experiments on the preparation of sodium bicarbonate and bismuth subcarbonate powder (Xipi's powder II)
Dispersions are dry powdery preparations of drugs or with suitable excipients made by crushing and uniform mixing for internal or topical use. Internal dispersions are usually dissolved or dispersed in water or other liquids, and can also be taken directly with water. Topical dispersions can be applied to the skin, mouth, throat, cavity, etc.; specifically for the purpose of treatment, prevention and lubrication of the skin for the purpose of the dispersions can also be referred to as spreading agent or spreading powder.
Operation method
Dispersed drug preparation method
Materials and Instruments
Xipi'san II Move 1. weighing: the correct choice of balance, to master a variety of agglomerated state of the weighing of drugs. Caveat 1. This product may be used alternately with Cipizzan I to correct the constipation caused by bismuth subcarbonate, or alone as appropriate. Bismuth subcarbonate can be replaced by precipitated calcium carbonate. For more product details, please visit Aladdin Scientific website.
Sodium bicarbonate Bismuth subcarbonate
mortar, sieve, balance
2. pulverization: is the preparation of bulk and the basic operation of the relevant dosage form. Require students according to the physical and chemical properties of drugs, the use of requirements, a reasonable choice of crushing tools and methods.
3 sieving: master the basic methods, clear sieving operation should pay attention to the problem. 4 mixing: mixing uniformity is the most common problem.
4. mixing: mixing uniformity is an important indicator of the quality of bulk, especially containing a small amount of toxic drugs for medical use and precious drugs in bulk, in order to ensure uniformity of mixing, should be used in equal incremental method (with the research method). Containing a small amount of volatile oil and eutectic components of the bulk, can be absorbed by other components of the prescription, and then mixed with other components.
5. Packaging: learn the packaging methods such as split-dose bulk package pentagonal package, four-cornered package, rectangular package and so on.
6. quality check: according to the pharmacopoeia.