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Leu-Gly-Gly - 98%, high purity , CAS No.1187-50-4

  • ≥98%
In stock
Item Number
L121359
Grouped product items
SKU Size Availability Price Qty
L121359-250mg
250mg
9
$54.90
L121359-1g
1g
9
$166.90
L121359-5g
5g
9
$536.90
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Basic Description

Synonyms (S)-2-(2-(2-Amino-4-methylpentanamido)acetamido)acetic acid | HY-W012003 | L-Leu-Gly-Gly | Q27144715 | [2-((S)-2-Amino-4-methyl-pentanoylamino)-acetylamino]-acetic acid | CHEBI:74538 | l-leucylglycylglycine | L-Leucyl-glycyl-glycine | 0962ABF0-21F5-4144-B
Specifications & Purity ≥98%
Biochemical and Physiological Mechanisms Leucylglycylglycine (DL-Leu-Gly-Gly) may be used to study the effects of branched-chain di- and tripeptides on cell envelope-associated proteinases (CEPs) activity. L-Leu-Gly-Gly may be used as a substrate to study the kinetics of tripeptide aminopeptidas
Storage Temp Store at -20°C
Shipped In Ice chest + Ice pads

AI Insight

Associated Targets(Human)

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC15A2 Tchem Solute carrier family 15 member 2 (186 Activities)
Activity Type Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

Mechanisms of Action

Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References

Names and Identifiers

Pubchem Sid 504754586
Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504754586
IUPAC Name 2-[[2-[[(2S)-2-amino-4-methylpentanoyl]amino]acetyl]amino]acetic acid
INCHI InChI=1S/C10H19N3O4/c1-6(2)3-7(11)10(17)13-4-8(14)12-5-9(15)16/h6-7H,3-5,11H2,1-2H3,(H,12,14)(H,13,17)(H,15,16)/t7-/m0/s1
InChi Key VWHGTYCRDRBSFI-ZETCQYMHSA-N
Canonical SMILES CC(C)CC(C(=O)NCC(=O)NCC(=O)O)N
Isomeric SMILES CC(C)C[C@@H](C(=O)NCC(=O)NCC(=O)O)N
WGK Germany 3
PubChem CID 70910
Molecular Weight 245.28
Beilstein 1728928

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot Number Certificate Type Date Item
K2223417 Certificate of Analysis Jul 15, 2022 L121359
K2223422 Certificate of Analysis Jul 15, 2022 L121359
K2223438 Certificate of Analysis Jul 15, 2022 L121359

Chemical and Physical Properties

Molecular Weight 245.280 g/mol
XLogP3 -3.000
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 7
Exact Mass 245.138 Da
Monoisotopic Mass 245.138 Da
Topological Polar Surface Area 122.000 Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 291.000
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
The total count of all stereochemical bonds 0
Covalently-Bonded Unit Count 1

Safety and Hazards(GHS)

WGK Germany 3

Specifications

 Specification Sheet

References

1. Biegel A, Gebauer S, Hartrodt B, Brandsch M, Neubert K, Thondorf I.  (2005)  Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1..  J Med Chem,  48  (13): (4410-9).  [PMID:15974593] [10.1021/op500134e]
2. T Agatsuma,S Habe.  (1985-12-01)  Electrophoretic studies on enzymes of diploid and triploid Paragonimus westermani..  Parasitology,  91   (( Pt 3)): (489-497).  [PMID:2934681]
3. S Kanda,K Sudo,T Kanno.  (1984-06-01)  A specific kinetic assay for tripeptide aminopeptidase in serum..  Clinical chemistry,  30  ((6)): (843-846).  [PMID:6723039]
4. G F Vaeth,S J Henning.  (1982-01-01)  Postnatal development of peptidase enzymes in rat small intestine..  Journal of pediatric gastroenterology and nutrition,  1  ((1)): (111-117).  [PMID:7186019]
5. Elvira María Hebert,Gianfranco Mamone,Gianluca Picariello,Raúl R Raya,Graciela Savoy,Pasquale Ferranti,Francesco Addeo.  (2008-04-22)  Characterization of the pattern of alphas1- and beta-casein breakdown and release of a bioactive peptide by a cell envelope proteinase from Lactobacillus delbrueckii subsp. lactis CRL 581..  Applied and environmental microbiology,  74  ((12)): (3682-3689).  [PMID:18424544]
6. Griet Van Zeebroeck,Beatriz Monge Bonini,Matthias Versele,Johan M Thevelein.  (2008-12-09)  Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor..  Nature chemical biology,  5  ((1)): (45-52).  [PMID:19060912]
7. María B Espeche Turbay,Graciela Savoy de Giori,Elvira M Hebert.  (2009-09-17)  Release of the cell-envelope-associated proteinase of Lactobacillus delbrueckii subspecies lactis CRL 581 is dependent upon pH and temperature..  Journal of agricultural and food chemistry,  57  ((18)): (8607-8611).  [PMID:19754175]
8. Alessandro Pedretti,Laura De Luca,Cristina Marconi,Luca Regazzoni,Giancarlo Aldini,Giulio Vistoli.  (2011-07-12)  Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping..  Bioorganic & medicinal chemistry,  19  ((15)): (4544-4551).  [PMID:21741846]
9. L C Masek,J W Sweetenham,J M Whitehouse,U Schumacher.  (1994-11-01)  Immuno-, lectin-, and enzyme-histochemical characterization of human bone marrow endothelium..  Experimental hematology,  22  ((12)): (1203-1209).  [PMID:7925783]

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